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KMID : 0383419690100030389
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Korean Modern Medical Journal
1969 Volume.10 No. 3 p.389 ~ p.394
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The influecne of on the lactic acid production by Osmotic gradients and Vasopression in the isolated kidney slices
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Abstract
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The present experiments were designed to examine in rabbit kidney cortex and inner medulla slices, the responses to the lactic acid production to osmotic gradiants as affected by vasopressin and by adenosine-triphosphate.
The os molarity of medium was :altered by changing the concentration of NaCl in the Krebs-Ringer bicarbonate solution, and the NaCl was replaced with urea.
The data demonstrate that
1) the lactic acid production in the medulla was two times in the cortex Media. In the cortex the lactic acid production was greatest in the media of 298mOsm/kg·H₂O, whereas it showed a periodic changes in the medulla as the osmolarity increased.
2) After addition of vasopressin, the lactic acid production was decreased in the media of 298mOsm/kg·H₂O but was increased in the media of 548mOsm/kg·H₂O.
3) The lactic acid production was not influenced by addition of ATP and interrelationship between vasopressin and ATP on the lactic acid production was obscure from this experiment.
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KEYWORD
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